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Bárbara Barbosa on Muck Rack

Bárbara Barbosa

As seen in: G1 Globo, Medium, Nature, Wiley Online Library, Oxford University Press (OUP), Sapo, MDPI, Publico (Portugal), Towards Data Science, Diário do Nordeste and
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Articles

Spatial structures of tumor and immune cells shape outcomes in ER⁺HER2⁻ and triple-negative breast cancer

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By Iris Nederlof, Siamak Hajizadeh, Rolf Harkes, Bárbara Barbosa, Michiel de Maaker, Ingrid Hofland, Dennis G Peters, Annegien Broeks, Erik van Werkhoven, Yongsoo Kim, Noel de Miranda, Joyce Sanders, Roberto Salgado, Philip Martin Poortmans, Astrid N. Scholten, Liesbeth J. Boersma, Marleen Kok, Harry Bartelink, Marc J. van de Vijver, Hugo M. Horlings, Robert Elens, Marieke Ijsselstein, Sophie Bosma, Nicole C. M. Visser, Malou L. H. Snijders
| Nature Verified
Abstract Immune infiltration is prognostic in triple-negative breast cancer (TNBC), but its role in ER⁺HER2− disease remains unclear, and conventional scoring may overlook spatial context. We analyzed tumors from 1,037 women ≤50 years in the Young Boost Trial (NCT00212121), integrating centralized pathology review, deep learning-based spatial profiling of whole-slide H&E, and multiplex immunophenotyping.
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Modifiable lifestyle factors and their association with depression and quality of life in community-dwelling older adults: a multicriteria index analysis

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By Luana Soares, Maria Oliveira, Bárbara Barbosa, Ana Trindade, Diana Cuéllar, Vanessa A. Mendonça, Leonardo A. C. Teixeira, Bernat Viñola Prat, Maria Fernanda S. Mourão, Geisy K. A. Silva, Letícia G. Amarante, Ronaldo L. Thomassini
| Nature Verified
Abstract Life habits can influence the aging process. However, there remains a gap in how these factors can associate frailty, independence in activities of daily living, depression and quality of life in older adults. (1) To develop an index to synthesize modifiable lifestyle factors of older adults of middle-income countries; (2) to check the relationship and the association of this index with frailty, independence in daily activities, depression and quality of life.
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Evaluation of a New Methylimidazole‐Containing Thiosemicarbazone as a Cu+/Cu2+‐Targeting Ligand in the Context of Alzheimer's Disease

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By Bárbara Barbosa, Charlène Esmieu, Mariana Costa, Antal Galvácsi
| Wiley Online Library Verified
1 Introduction Copper is an essential trace element in biological systems, being required as a structural component, electron transporter agent and cofactor of redox enzymes, including Cu/Zn superoxide dismutase (SOD1) or cytochrome c oxidase, that play a critical role in antioxidant defense and mitochondrial respiratory chain, respectively [1, 2]. In the nervous system, this metal actively participates in neurotransmitter biosynthesis, cognitive processes and gene expression [3].
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