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Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle

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By Mushtaq A. Nengroo, Austin Klein, Heather Carr, Olivia Vidal-Cruchez, Umakant Sahu, Daniel J. McGrail, Nidhi Sahni, Niklas B. Thompson, Peter A. Faull, Peng Gao, John M. Asara, Hardik Shah, Marc L. Mendillo, Issam Ben-Sahra
| Cell Press Verified
Keywords nucleotide metabolism mitochondrial metabolism cancer succinate TCA cycle formate Introduction The tricarboxylic acid (TCA) cycle is a central metabolic hub that not only generates energy but also provides critical building blocks for biosynthetic processes.1 Traditionally, the TCA cycle has been viewed primarily as an engine for oxidative phosphorylation, where the oxidation of nutrients produces reducing equivalents, such as NADH (nicotinamide adenine dinucleotide [reduced]) and...
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