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Heather E. Fleming

As seen in: Nature, Science Magazine, Cell Host & Microbe, Cell Press, Wyoming Tribune Eagle
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Articles by Heather E. Fleming

CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics - Nature Nanotechnology

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By Liangliang Hao, Renee T. Zhao, Henry Ko, Heather E. Fleming, Nour Saida Harzallah, Chayanon Ngambenjawong
| Nature Verified
Abstract Synthetic biomarkers, bioengineered sensors that generate molecular reporters in diseased microenvironments, represent an emerging paradigm in precision diagnostics. Despite the utility of DNA barcodes as a multiplexing tool, their susceptibility to nucleases in vivo has limited their utility. Here we exploit chemically stabilized nucleic acids to multiplex synthetic biomarkers and produce diagnostic signals in biofluids that can be ‘read out’ via CRISPR nucleases.
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Fleming and Roden: Embracing Literacy Conference designed for teachers, parents

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By Heather E. Fleming, Kari Roden
| Wyoming Tribune Eagle Verified
If you teach or parent a child who is learning to read, the Embracing Literacy Conference was designed with you in mind. The conference is being sponsored by the Wyoming Department of Education and the University of Wyoming. WY Lit is honored to have recommended 15 of the 18 speakers. The conference started on Tuesday, July 21, and will continue every Tuesday and Thursday through Aug. 11. All sessions are being recorded, and you may register until Aug 11. kAm%96 4@?76C6?46 @A6?65 @? %F6D52JkDA2?
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Fleming and Roden: Reading comprehension is an outcome, not one specific skill

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By Heather E. Fleming, Kari Roden
| Wyoming Tribune Eagle Verified
Reading comprehension is a complex and often oversimplified term. RC is an outcome, not one specific skill. RC is the result of foundational reading skills intertwined with vocabulary, background knowledge, an understanding of how words and phrases work together, and strategies used to analyze and understand different kinds of writing. The problem is that many people talk about RC as if it were an isolatable skill. kAm(96? 2 49:=5 AC6D6?ED H:E9 H92E 2AA62CD E@ 36 2?
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Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers

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By Liliana Mancio-Silva, Alex Miller, Stuart Milstein, Heather E. Fleming
| Cell Press Verified
Highlights • Engineered human microlivers enable robust long-term nucleic acid-mediated silencing • Human microlivers support assessment of hepatic-targeted nucleic acid-based therapies • siRNA-mediated silencing effectively modifies hepatocyte drug metabolism Summary The liver plays a central role in metabolism; however, xenobiotic metabolism variations between human hepatocytes and those in model organisms create challenges in establishing functional test beds to detect the potential drug...
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