Héctor Leal Lassalle on Muck Rack

Héctor Leal Lassalle

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Articles

Identification of ACBP as a potential target in ciliopathic obesity through multi-omics network analysis - Nature Communications

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By Laura Ventura-San Pedro, Sonia Paredes Verified, Ana Elena Pérez-Cobas, Paula Moreno-Cruz, Rocío Benítez-Fernández, Yulia A Nevzorova, Francisco Javier Cubero, Élida Alechaga, Oscar J Pozo, José Fuentes, Valentina Sica, Guido Kroemer, Héctor Leal Lassalle
| Nature Verified
Abstract Ciliopathies are genetic disorders characterized by defective primary cilia function, with obesity as a clinical manifestation in certain cases, including Alström syndrome, which is caused by ALMS1 mutations. The link between cilia and lipid metabolism remains poorly understood, but evidence suggests a role for impaired autophagy. Autophagy affects both intra- and extracellular levels of ACBP, which can act as an obesogenic factor.
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