Hee-Won Bae

Abstract Lytic phages culminate their lifecycle by causing lysis of the infected host cell. Despite extensive research on the molecular mechanisms of phage lysis, our understanding of anti-phage resistance mechanisms during the lysis stage remains less understood.

Introduction Pseudomonas aeruginosa (PA) is a well-known nosocomial pathogen that causes life-threatening infections especially in patients suffering from burn, cancer chemotherapy, chronic pulmonary diseases, and cystic fibrosis. PA infections are more and more difficult to treat due to the emergence of antibiotic resistance, thus resulting in severe outcomes worldwide and limited choices for therapeutic options (4, 6).