Heiwa So on Muck Rack

Heiwa So

As seen in: Nature
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Articles

Osteoblastic sclerostin loop3-LRP4 interaction required by sclerostin to inhibit bone formation

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By Luyao Wang, Xiaohui Tao, Shijian Ding, Ning Zhang, Xin Yang, Shenghang Wang, Yihao Zhang, Nanxi Li, Haitian Li, Zhanghao Li, Xiaoxin Wen, Meiheng Sun, Chuanxin Zhong, Jin Liu, Yuanyuan Yu, Hua Yue, Péter Ferdinandy, Tao Zhang, Shu Zhang, Zhenlin Zhang, Aiping Lu, Baoting Zhang, Ge Zhang, Hewen Jiang, Heiwa So, Xianghang Luo
| Nature Verified
Abstract Sclerostin negatively regulates bone formation. The marketed antibody against sclerostin loop2 promoted bone formation but may have caused severe cardiovascular events in clinical use. In our published studies, sclerostin loop3 was found to be involved in inhibitory effects of sclerostin on bone formation, whereas cardiovascular protective effects of sclerostin in mice were independent of loop3.
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