Heleia Roca-Ho on Muck Rack

Heleia Roca-Ho

As seen in: Nature, Cell Reports, Blood
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Articles

Hyperdiploidy impairs fetal hematopoietic progenitor fitness and differentiation enabling persistence of rare preleukemic aneuploid clones

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By Namitha Thampi, Cristina Baizán Calvo, Alba Martinez-Moreno, Heleia Roca-Ho, Meritxell Vinyoles, Clara Bueno, Jordi Camps, Xose S. Puente, Francesc Solé, Floris Foijer, Pablo Menéndez Verified, Oscar Molina, Virginia Rodríguez-Cortez, Verónica Pablo-Fontecha, Ana de la Fuente-González
| Cell Reports Verified
Results Hyperdiploid karyotypes are thought to arise in HSPCs through either a single abnormal mitosis that results in the simultaneous gain of multiple chromosomes or via the formation of a tetraploid intermediary that then evolves clonally, ultimately generating the stereotypical HeH karyotypes observed in cB-ALL.36 To investigate the impact of hyperdiploidy on prenatal HSPCs and its contribution to the initiation of HeH-B-ALL, we modeled these two proposed origins in CD34+ hFL-HSPCs...
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Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia

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By Diego Sanchéz-Martínez, Matteo L. Baroni, Francisco Gutiérrez-Agüera, Heleia Roca-Ho
| Blood Verified
Diego Sánchez-Martínez, Matteo L. Baroni, Francisco Gutierrez-Agüera, Heleia Roca-Ho, Oscar Blanch-Lombarte, Sara González-García, Montserrat Torrebadell, Jordi Junca, Manuel Ramírez-Orellana, Talía Velasco-Hernández, Clara Bueno, José Luís Fuster, Julia G.
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Fratricide-resistant CD1a-specific CAR T-cells for the treatment of cortical T-cell acute lymphoblastic leukemia

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By Diego Sanchéz-Martínez, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Matteo L. Baroni
| Blood Verified
Diego Sánchez-Martínez, Matteo L. Baroni, Francisco Gutierrez-Agüera, Heleia Roca-Ho, Oscar Blanch-Lombarte, Sara González-García, Montserrat Torrabadell, Jordi Junca, Manuel Ramírez-Orellana, Talía Velasco-Hernández, Clara Bueno, José Luís Fuster, Julia G.
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