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Helen Hope on Muck Rack

Helen Hope

As seen in: Medium, Nature, Wiley Online Library, Flipboard, The Skimm, Dance Magazine, Dialnet - Universidad de La Rioja, Dance Spirit, Pointe, Dance Teacher and
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Articles

Modos de vida y formas diferenciales de uso-ocupación del paisaje en el Formativo Tardío: Los Montes de María en la arqueología del Bajo Magdalena y el Caribe colombiano

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By Gutiérrez Olano, Helen Hope, Gonzalez Fernandez, Javier Gutiérrez Olano
| Dialnet - Universidad de La Rioja
Ayuda Buscar en la ayuda Buscar en la ayuda Modos de vida y formas diferenciales de uso-ocupación del paisaje en el Formativo Tardío: Los Montes de María en la arqueología del Bajo Magdalena y el Caribe colombiano Autores: Javier Gutiérrez Olano Directores de la Tesis: Helen Hope Henderson (dir. tes.), Víctor González Fernández (codir.
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Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure - Nature Cancer

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By Helen Hope, Pierpaolo Ginefra, Massimo Andreatta, Christine Pich-Bavastro, Jesús Corria Osorio, François Kuonen, Ping-Chih Ho, Santiago J Carmona, George Coukos, Denis Migliorini
| Nature Verified
Abstract Chimeric antigen receptor (CAR) T cell therapy is one of the most promising cancer treatments. However, different hurdles are limiting its application and efficacy. In this context, how aging influences CAR-T cell outcomes is largely unknown. Here we show that CAR-T cells generated from aged female mice present a mitochondrial dysfunction derived from nicotinamide adenine dinucleotide (NAD) depletion that leads to poor stem-like properties and limited functionality in vivo.
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PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function - Nature

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By Matteo Morotti, Alizée J. Grimm, Helen Hope, Marion Arnaud, David Barras, Catherine Ronet, Aspram Minasyan, Johanna Chiffelle, Fabrizio Benedetti, Riccardo Turrini, Khalil Zaman, Marcus Conrad, Lana E. Kandalaft, Julien Dagher, Jesus Corria-Osorio, Ping-Chih Ho, Alexandre Harari, Nicola Vannini, Jan P. Böttcher, Denarda Dangaj Laniti
| Nature Verified
Abstract Expansion of antigen-experienced CD8+ T cells is critical for the success of tumour-infiltrating lymphocyte (TIL)-adoptive cell therapy (ACT) in patients with cancer1. Interleukin-2 (IL-2) acts as a key regulator of CD8+ cytotoxic T lymphocyte functions by promoting expansion and cytotoxic capability2,3.
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