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Helena Barysz on Muck Rack

Helena Barysz

As seen in: Cell Press
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Articles

Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

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By Chantal Garand, Guillaume Combes, Helena Barysz, Luciano Gama Braga
| Cell Press Verified
Dissection of the NTE Reveals an Autoinhibitory Motif Regulating Kinase Activity   The Mps1 NTE Interacts Directly with the Kinase Domain   Mps1 NTE-Mediated Relief of Autoinhibition Is Required for SAC Activity, but Not Chromosome Segregation Fidelity Our data thus far suggest that the Mps1 NTE promotes high local concentrations of the kinase at kinetochores, which contributes to its own optimal activation. We next sought to determine the specific region of the NTE that drives this process.
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