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Articles by Heming Wang
Bistable origami robot for adaptive multimodal motion actuated by nonuniform magnetic fields
Abstract Conventional magnetically controlled mini-robots require operation within highly uniform and high-precision magnetic fields, which are impractical for large space applications. In this work, the bistable origami robot offloads these requirements onto the pre-programmed geometry of its mechanical architecture. These structures exhibit distinct deformation modes at each stable state when subjected to small-amplitude magnetic perturbations.
[2601.22934] Prescribed $T$-curvature flow on the four-dimensional unit ball
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Doubling of the global freshwater footprint of material production over two decades - Nature Sustainability
Declining demand and circular transition possibilities of sand, gravel and crushed stone in China - Nature Communications
Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus in Hispanic and Latino communities - Communications Medicine
Abstract Obstructive sleep apnea (OSA), and other sleep disorders, are associated with increased risk of developing diabetes mellitus (DM). We examined whether sleep disorders influence the genetic risk of developing diabetes in Hispanic/Latino individuals. We developed Type 2 Diabetes (T2D) polygenic risk score (T2D-PRS) useful in admixed Hispanic/Latino individuals.
Genetic Associations Between Sleep Traits and Cognitive Ageing Outcomes in the Hispanic Community Health Study/Study of Latinos
BACKGROUND: Sleep phenotypes have been reported to be associated with cognitive ageing outcomes. However, there is limited research using genetic variants as proxies for sleep traits to study their associations. We estimated associations between Polygenic Risk Scores (PRSs) for sleep duration, insomnia, daytime sleepiness, and obstructive sleep apnoea (OSA) and measures of cogntive ageing in Hispanic/Latino adults.
cRare Coding Variants in RCN3 Are Associated With Blood Pressure
BACKGROUND: While large genome-wide association studies have identified nearly one thousand loci associated with variation in blood pressure, rare variant identification is still a challenge. In family-based cohorts, genome-wide linkage scans have been successful in identifying rare genetic variants for blood pressure.
Virus-host interactome reveals host cellular pathways perturbed by tick-borne encephalitis virus infection
Abstract Tick-borne encephalitis virus (TBEV) poses an increasingly significant threat to public health. Here, we delved into the virus-host interactome and discovered that TBEV has a profound impact on multiple host cellular pathways. Viral pre-membrane protein (prM), non-structural proteins NS1, NS2B3, NS4A, and NS5 remodel the host's innate immune responses.
The Corrosion Resistance Study of Ni‐P‐CS Coating Improved by Carbon Nanoparticle
References 1, , , and , “Efficacy of Corrosion Phenomena, Challenges and Control in Steel Industry: An Overview,” Journal of Physics: Conference Series 1378 (2019): 032055, https://doi.org/10.1088/1742-6596/1378/3/032055. 2, , and , “Modeling of Metal Structure Corrosion Damage: A State of the Art Report,” Sustainability 2 (2010): 2163–2175, https://doi.org/10.3390/su2072163.
Evaluation of the Effects of Acorns on the Meat Quality and Transcriptome Profile of Finishing Yuxi Pigs
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The disparities and development trajectories of nations in achieving the sustainable development goals - Nature Communications
Abstract The Sustainable Development Goals (SDGs) provide a comprehensive framework for societal progress and planetary health. However, it remains unclear whether universal patterns exist in how nations pursue these goals and whether key development areas are being overlooked. Here, we apply the product space methodology, widely used in development economics, to construct an ‘SDG space of nations’.
Multi-stable origami with thick panels
Keywords thick origami multi-stable structures multi-compatibility morphing structures deployable structures Introduction Origami mechanisms have richly designable morphing ability and have been applied in soft robots,1,2 space-deployable structures,3 morphing matters,4,5,6 and mechanical metamaterials.7,8,9 In many applications, the panels are required to have significant thickness to bear loads, and thus thick-panel origami is needed.
The evolution of research at the intersection of industrial ecology and artificial intelligence
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description jiec13612-sup-0001-SuppMat.docx163.7 KB Supporting Information S1: This supporting information provides. Appendix 1: Details of the retrieved content. Appendix 2: Data preprocessing. Appendix 3: Historical trends of publications and keywords. Appendix 4: Research topic trending patterns.
Pole and zero edge state invariant for one-dimensional non-Hermitian sublattice symmetry
There have been several criteria for the existence of topological edge states in 1D non-Hermitian two-band sublattice-symmetric tight-binding Hamiltonians. The generalized Brillouin zone (GBZ) approach uses the integration of the Berry connection over the GBZ contour in the complex wavevector space. An alternate ‘pole-zero’ approach uses algebraic properties of the off-diagonal matrix elements of the sublattice-symmetric Hamiltonian in off-diagonal form.
Multi-protomics analysis identified host cellular pathways perturbed by tick-borne encephalitis virus infection - Nature Communications
Abstract Tick-borne encephalitis virus (TBEV) represents a pivotal tick-transmitted flavivirus responsible for severe neurological consequences in Europe and Asia.
Association between Accelerometer-Measured Irregular Sleep Duration and Longitudinal Changes in Body Mass Index in Older Adults
Conflicts of Interest: MKR reports receiving consultancy fees from Eli Lilly and has modest stock ownership in GSK, unrelated to this work. The other authors have no conflicts of interest to declare. This work was supported by the National Institutes of Health (R01HL155395) and the UKB project 85501. SK was supported by the American Heart Association Postdoctoral Fellowship (https://doi.org/10.58275/AHA.24POST1188091.pc.gr.190780).
DNA origami assembled spheroid for evaluating cytotoxicity and infiltration of chimeric antigen receptor macrophage (CAR-M) - Communications Biology
Abstract Chimeric antigen receptor (CAR) T-cell therapies have shown remarkable results in patients with hematological malignancies. However, their success in treating solid tumors has been limited. As an alternative candidate for the CAR therapy, CAR-macrophages (CAR-M) have demonstrated activation and phagocytosis directed by tumor-associated antigen (TAA), showing promise in the treatment of solid tumors.
Efficient Photoelectrocatalytic Reduction of CO2 to Selectively Produce Ethanol Using FeS2/TiO2 p–n Heterojunction Photoelectrodes Original
Energy, Environmental, and Catalysis ApplicationsSeptember 20, 2024 Yue Tian School of Physical Science and Technology, Guangxi Normal University, Guilin 541004, People’s Republic of China * Lizhen Long School of Physical Science and Technology, Guangxi Normal University, Guilin 541004, People’s Republic of China Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, People’s Republic of China *Email: longlzh@foxmail.com Heming Wang School of...
Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus: The Hispanic Community Health Study/Study of Latinos
Dr. Redline discloses consulting relationships with Eli Lilly Inc. Additionally, Dr. Redline serves as an unpaid member of the Apnimed Scientific Advisory Board, as an unpaid board member for the Alliance for Sleep Apnoea Partners and for the National Sleep Foundation.
A Large-Scale Genome-Wide Gene-Sleep Interaction Study in 732,564 Participants Identifies Lipid Loci Explaining Sleep-Associated Lipid Disturbances
HJG has received travel grants and speakers honoraria from Neuraxpharm, Servier, Indorsia and Janssen Cilag. LMR is a consultant for the TOPMed Administrative Coordinating Center (through Westat). TDS is co-founder and shareholder of ZOE Ltd. All other co-authors declare to have no conflicts of interest. This project was largely supported by two grants from the U.S. National Heart, Lung, and Blood Institute (NHLBI), the National Institutes of Health, R01HL118305 and R01HL156991.
Sleep duration irregularity and risk for incident cardiovascular disease in the UK Biobank
The authors have declared no competing interest. The study is not a trial. This research was supported by NIH grant R01HL155395, UK Biobank project 85501 and the Intramural Research Program of the NIH, National Institute on Aging. SK was supported by the American Heart Association Postdoctoral Fellowship (24POST1188091). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Substantial increase in China’s manufactured sand supply since 2010 - Nature Geoscience
Abstract As the world’s second most consumed resource, sand is being depleted at an alarming rate. China accounted for nearly half of the world’s sand consumption in 2012. Here we present a material flow analysis of sand from 1995 to 2020 that shows China’s overall sand supply surged by approximately 400% over the study period, yet the proportion of natural sand dropped from ~80% to ~21% due to the increasing use of manufactured sand.
The Effects of Poria cocos Polysaccharides on Growth Performance, Immunity, and Cecal Microflora Composition of Weaned Piglets
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
"Whole-genome association analyses of sleep-disordered breathing phenot" by Brian E Cade, Jiwon Lee et al.
BACKGROUND: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing. METHODS: The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals.
Comparison of Growth Performance, Carcass Properties, Fatty Acid Profile, and Genes Involved in Fat Metabolism in Nanyang and Landrace Pigs
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
DNA origami assembled spheroid for evaluating cytotoxicity and infiltration of chimeric antigen receptor macrophage (CAR-M)
Abstract Chimeric antigen receptor (CAR) T-cell therapies have shown remarkable results in patients with hematological malignancies. However, their success in treating solid tumors has been limited. As an alternative candidate for the CAR approach, CAR-macrophages (CAR-M) have demonstrated activation and phagocytosis directed by tumor antigens, showing promise in the treatment of solid tumors.
Soliton pulse pairs at multiple colours in normal dispersion microresonators - Nature Photonics
Abstract Soliton microcombs are helping to advance the miniaturization of a range of comb systems. These combs mode lock through the formation of short temporal pulses in anomalous dispersion resonators. Here, a new microcomb is demonstrated that mode locks through the formation of pulse pairs in coupled normal dispersion resonators.
3D integration enables ultralow-noise isolator-free lasers in silicon photonics - Nature
3D mode transitions Using a series of adiabatic tapers56, the optical mode is transferred over a vertical distance exceeding 4.8 μm between an InP/Si hybrid mode in the laser active region, to the ULL SiN waveguide layer of the ultrahigh-Q resonator. The mode is transferred first from the InP/Si hybrid waveguide into a Si waveguide and subsequently from the Si waveguide into a SiN RDL.
A Low-Latency, Low-Jitter Retimer Circuit for PCIe 6.0
4. Retimer Circuit Simulation The retimer circuit designed in this paper is simulated at schematic level on the Candence platform (input signal is 112 Gbps PAM4, sinusoidal jitter frequency is 1 MHz, amplitude is 0.1 UI, clock frequency is 14 GHz, no frequency difference) to measure its delay and jitter performance.
Universal embedding of a non-Hermitian reciprocal scattering optical system into a Hermitian time-reversal-invariant system
Abstract For Hermitian optical systems, reciprocity and time-reversal symmetry are equivalent. In non-Hermitian systems that have gain and/or loss, however, they are not equivalent. Here, we point out a connection between reciprocity and time-reversal symmetry in general. For a non-Hermitian system, we show that reciprocity can be viewed as a manifestation of the time-reversal symmetry of an enclosing Hermitian system.
Quantum decoherence of dark pulses in optical microresonators - Nature Communications
Abstract Quantum fluctuations disrupt the cyclic motions of dissipative Kerr solitons (DKSs) in nonlinear optical microresonators and consequently cause timing jitter of the emitted pulse trains. This problem is translated to the performance of several applications that employ DKSs as compact frequency comb sources.
An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling - Communications Biology
Abstract Sleep Disordered Breathing (SDB) is a common disease associated with increased risk for cardiometabolic, cardiovascular, and cognitive diseases. How SDB affects the molecular environment is still poorly understood. We study the association of three SDB measures with gene expression measured using RNA-seq in multiple blood tissues from the Multi-Ethnic Study of Atherosclerosis.
Self-regulating soliton switching waves in microresonators
Abstract Dissipative soliton Kerr frequency combs in microresonators have recently been demonstrated with the self-injection locking process. In addition to turnkey deterministic comb generation, this mode of operation simplifies dark pulse generation in the normal dispersion regime. Here, the formation process of dark pulses triggered by self-injection locking is studied by regarding them as a pair of switching waves that connect domains having different intracavity powers.
Extending the spectrum of fully integrated photonics to submicrometre wavelengths - Nature
Abstract Integrated photonics has profoundly affected a wide range of technologies underpinning modern society1,2,3,4. The ability to fabricate a complete optical system on a chip offers unrivalled scalability, weight, cost and power efficiency5,6.
Integrated Pockels laser - Nature Communications
Abstract The development of integrated semiconductor lasers has miniaturized traditional bulky laser systems, enabling a wide range of photonic applications. A progression from pure III-V based lasers to III-V/external cavity structures has harnessed low-loss waveguides in different material systems, leading to significant improvements in laser coherence and stability. Despite these successes, however, key functions remain absent.
Hertz-linewidth semiconductor lasers using CMOS-ready ultra-high-Q microresonators
Abstract Driven by narrow-linewidth bench-top lasers, coherent optical systems spanning optical communications, metrology and sensing provide unrivalled performance. To transfer these capabilities from the laboratory to the real world, a key missing ingredient is a mass-produced integrated laser with superior coherence.
Genetic determinants of daytime napping and effects on cardiometabolic health
Abstract Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide association study of self-reported daytime napping in the UK Biobank (n = 452,633) and identify 123 loci of which 61 replicate in the 23andMe research cohort (n = 541,333).
Quantum diffusion of microcavity solitons
Abstract Coherently pumped (Kerr) solitons in an ideal optical microcavity are expected to undergo random quantum motion that determines fundamental performance limits in applications of the soliton microcombs1. Here this random walk and its impact on Kerr soliton timing jitter are studied experimentally. The quantum limit is discerned by measuring the relative position of counter-propagating solitons2.
Greater than one billion Q factor for on-chip microresonators
Abstract High optical quality (Q) factors are critically important in optical microcavities, where performance in applications spanning nonlinear optics to cavity quantum electrodynamics is determined. Here, a record Q factor of over 1.1 billion is demonstrated for on-chip optical resonators. Using silica whispering-gallery resonators on silicon, Q-factor data is measured over wavelengths spanning the C/L bands (100 nm) and for a range of resonator sizes and mode families.
Integrated turnkey soliton microcombs
Abstract Optical frequency combs have a wide range of applications in science and technology1. An important development for miniature and integrated comb systems is the formation of dissipative Kerr solitons in coherently pumped high-quality-factor optical microresonators2,3,4,5,6,7,8,9. Such soliton microcombs10 have been applied to spectroscopy11,12,13, the search for exoplanets14,15, optical frequency synthesis16, time keeping17 and other areas10.
Interleaved difference-frequency generation for microcomb spectral densification in the mid-infrared
M. Jankowski, C. Langrock, B. Desiatov, A. Marandi, C. Wang, M. Zhang, C. R. Phillips, M. Lončar, and M. Fejer, “Ultrabroadband nonlinear optics in nanophotonic periodically poled lithium niobate waveguides,” Optica 7, 40–46 (2020). [Crossref] M. Zhang, B. Buscaino, C. Wang, A. Shams-Ansari, C. Reimer, R. Zhu, J. M. Kahn, and M. Lončar, “Broadband electro-optic frequency comb generation in a lithium niobate microring resonator,” Nature 568, 373–377 (2019). [Crossref] Y. He, Q.-F. Yang, J. Ling, R. Luo, H. Liang, M. Li, B.
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates - Nature Communications
Abstract Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p < 5 × 10−8; 43 loci at p < 6 × 10−9). Replication is observed for PAX8, VRK2, and FBXL12/UBL5/PIN1 loci in the CHARGE study (n = 47,180; p < 6.3 × 10−4), and 55 signals show sign-concordant effects.
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