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Hendrik Bartolomaeus on Muck Rack

Hendrik Bartolomaeus

As seen in: Nature, Wiley Online Library, BioRxiv, Journal of the American Society of Nephrology (JASN)
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Articles

Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension

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By Moritz Wimmer, Freie Universität Berlin, Hendrik Bartolomaeus, Harithaa Anandakumar
| Wiley Online Library Verified
1 INTRODUCTION Metformin, a long-established first-line medication for type 2 diabetes,1 has attracted the attention of researchers for its potential benefits beyond diabetes.
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Baseline microbiome composition impacts resilience to and recovery following antibiotics

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By Chia-Yu Chen, Ulrike Loeber, Hendrik Bartolomaeus, Lisa A. Maier
| BioRxiv
Abstract The gut microbiome of healthy individuals naturally undergoes temporal changes linked to the dynamics of its community components. These dynamics are only observable in longitudinal studies; they are particularly relevant to understanding ecosystem responses to external environment disturbances. External exposures, such as antibiotic treatment, significantly reshape the gut microbiome, impacting both pathogen and commensal microbes.
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Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung - Nature Communications

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By Facundo Fiocca Vernengo, Ulrike Bruning, Florian Kurth, Miha Milek, Ulrike Löber, Gitta Anne Heinz, Mir-Farzin Mashreghi, Stefan Offermanns, Matthias Mack, Stefan Jordan, Sofia K. Forslund, Nicola Wilck, Hendrik Bartolomaeus, Ivo Röwekamp, Belén Millet Pascual-Leone, Marta Krzanowski, Josua Sellmaier, Sandra-Maria Wienhold
| Nature Verified
Abstract Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy is a major risk factor for HAP, the underlying mechanism remains incompletely understood. Here, we demonstrate that antibiotic therapy in hospitalized patients is associated with decreased diversity of the gut microbiome and depletion of short-chain fatty acid (SCFA) producers.
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