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Josua Sellmaier on Muck Rack

Josua Sellmaier

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Articles

Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung - Nature Communications

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By Facundo Fiocca Vernengo, Ulrike Bruning, Florian Kurth, Miha Milek, Ulrike Löber, Gitta Anne Heinz, Mir-Farzin Mashreghi, Stefan Offermanns, Matthias Mack, Stefan Jordan, Sofia K. Forslund, Nicola Wilck, Hendrik Bartolomaeus, Ivo Röwekamp, Belén Millet Pascual-Leone, Marta Krzanowski, Josua Sellmaier, Sandra-Maria Wienhold
| Nature Verified
Abstract Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy is a major risk factor for HAP, the underlying mechanism remains incompletely understood. Here, we demonstrate that antibiotic therapy in hospitalized patients is associated with decreased diversity of the gut microbiome and depletion of short-chain fatty acid (SCFA) producers.
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