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Heng Yin on Muck Rack

Heng Yin

As seen in: Nature, Wiley Online Library, arXiv, MDPI, ACS Publications, American Chemical Society, Royal Society of Chemistry, Dialnet - Universidad de La Rioja, JoVE- Journal of Visualized Experiments, Chemistry World and
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Articles

Diastereoselective Construction of Bispirooxindole Pyrazolines by [3 + 2] Annulation

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By Jian Wang, Song Hu, Heng Yin
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the supporting information of this article. Supporting Information Filename Description ejoc70752-sup-0001-SuppData-S1.pdf4.9 MB Supplementary Material References 1, , , et al., “4-[5-Methyl-3‍-‍phenylisoxazol-4-yl]-benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2,” Journal of Medicinal Chemistry 43 (2000): 775.
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Identification of Kukoamine B from Lycii Radicis Cortex as a PD-L1 inhibitor against lung cancer

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By Meng Liu, Wanwan He, Lisheng Zhang, Meiling Chen, Yu Lu Wei, Na Huang, Danna Zheng, Shuxian Wang, Wen Zhang, Na Liu, Yali Huang, Heng Yin, Ren Zhang, Rutong Wu
| Nature Verified
Abstract Lycii Radicis Cortex (LRC), a medicinal and edible resource, has shown anti-lung cancer activity by disrupting the PD-1/PD-L1 interaction and reactivating T cells, but its active constituent remains unclear. Herein, we trained five machine learning models to predict the IC₅₀ values for PD-L1 inhibitors. Among them, the random forest regression algorithm showed superior performance and was used to prioritize LRC-derived candidates for experimental validation.
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Reactive oxygen species/glutathione dual responsive nanocarrier co-delivers pesticide and chitosan oligosaccharide for enhanced control of crop disease

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By Yiying Jiang, Ruixin Li, Heng Yin
| Wiley Online Library Verified
CONFLICT OF INTEREST The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. REFERENCES 1, , , , and , Advances in stimuli-responsive systems for pesticides delivery: recent efforts and future outlook. J Control Release 352: 288–312 (2022).
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