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Henry Barreras on Muck Rack

Henry Barreras

As seen in: Science Magazine, The Journal of Clinical Investigation
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Articles

Minnelide suppresses GVHD and enhances survival while maintaining GVT responses

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By JCI Insight, Sabrina N. Copsel, Vanessa T. Garrido, Henry Barreras
| The Journal of Clinical Investigation
ResearchImmunologyTransplantation Open Access | 10.1172/jci.insight.165936 JCI Insight. https://doi.org/10.1172/jci.insight.165936. Copyright © 2024, Copsel et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Allogeneic hematopoietic stem cell transplantation (aHSCT) can cure patients with otherwise fatal leukemias and lymphomas.
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STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets

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By Cameron S. Bader, Henry Barreras, Casey O. Lightbourn, Sabrina N. Copsel
| Science Magazine Verified
Avoiding the STING of GVHD Stimulator of interferon genes (STING) is important for gut homeostasis and has been shown to be protective against experimental GVHD after MHC-mismatched allogeneic hematopoietic stem cell transplantation (aHSCT). In contrast, Bader et al. observed that STING promoted GVHD in mouse models of MHC-matched aHSCT. This seemingly paradoxical result was due to GVHD being driven by different types of T cells in the MHC-matched or MHC-mismatched models.
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