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Should Metformin Continue as First-Line Pharmacotherapy for Patients With Type 2 Diabetes? No: Other Drugs Have Stronger Evidence of Benefit
Am Fam Physician. 2024;109(3):202-203 Related Editorial: Should Metformin Continue as First-Line Pharmacotherapy for Patients With Type 2 Diabetes? Yes: Metformin Is Still the Best Choice This is one in a series of pro/con editorials discussing controversial issues in family medicine. Author disclosure: No relevant financial relationships.
Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-Analysis
Abstract PURPOSE We conducted a meta-analysis to evaluate clinically meaningful benefits and harms of monoclonal antibodies targeting amyloid in patients with Alzheimer dementia. METHODS We searched PubMed, Cochrane CENTRAL, and 5 trial registries, as well as the reference lists of identified studies. We included randomized controlled trials comparing a monoclonal antibody with placebo at a dose consistent with that used in phase 3 trials or for Food and Drug Administration approval.
Morning and Bedtime Dosing of Antihypertensives Have Similar Rates of Major Cardiovascular Events
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