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Given the evolutionary conservation of both vacuole/lysosome acidification mechanisms (via V-ATPase) and the contacts between mitochondria and vacuole/lysosome,28,29 we then asked whether mitochondria-lysosome contacts play a similar role in the acidification of lysosomes in cultured human cells.
Abstract The remarkable capability of Tardigrade to survive under extreme conditions has been partially attributed to Dsup, an intrinsically disordered, highly positively charged protein. Dsup has been shown to bind to DNA in vitro, a property that has been associated with the capability of Dsup to exhibit stress-protective effects when expressed in mammalian cells.
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