Jun-Wei B. Hughes on Muck Rack

Jun-Wei B. Hughes

As seen in: Cell Press
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Mitochondria-lysosome coupling contributes to lysosome acidification and aging

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By Qingqing Liu, Seungmin Yoo, Zhixin Zhang, Liying Li, Hetian Su, Lingraj Vannur, Alexandra C Wooldredge, Pierre-Yves Desprez, Nan Hao, Gordon J. Lithgow, Julie Andersen, Malene Hansen, Judith Campisi, Chuankai Zhou, Jun-Wei B. Hughes
| Cell Press
Results Using a well-established fluorescent probe for vacuole acidification,16,17 we serendipitously discovered that overexpression of the mitochondrial import receptor protein TOM70 (Tom70 OE) from different promoters, which preserves mitochondrial membrane potential (MMP) during aging,18 prevented age-associated vacuole de-acidification in yeast (Figures 1A–1C and S1A–S1D).
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