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Hieu S. Vu on Muck Rack

Hieu S. Vu

As seen in: Cell Press, The Journal of Clinical Investigation
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Articles by Hieu S. Vu

The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity

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By Maud Maillard, Rina Nishii, Hieu S. Vu, Kashi R. Bhattarai
| The Journal of Clinical Investigation
Abstract Thiopurines are anticancer agents used for the treatment of leukemia and autoimmune diseases. These purine analogs are characterized by a narrow therapeutic index because of the risk of myelosuppression. With the discovery of NUDIX hydrolase 15 (NUDT15) as a major modulator of thiopurine metabolism and toxicity, we sought to comprehensively examine all members of the NUDIX hydrolase family for their effect on the pharmacologic effects of thiopurine.
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A male-derived nonribosomal peptide pheromone controls female schistosome development

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By Rui Chen, Jipeng Wang, Irina Gradinaru, Hieu S. Vu
| Cell Press Verified
Highlights • gli1 is essential for male schistosomes to induce female sexual development • Male:female pairing induces male Sm-nrps expression in a gli1-dependent manner • Sm-nrps is essential for male worms to induce female sexual development • SmNRPS makes β-alanyl-tryptamine, a pheromone that stimulates female development Summary Schistosomes cause morbidity and death throughout the developing world due to the massive numbers of eggs female worms deposit into the blood of their host.
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