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High-Throughput Genomics

As seen in: Cell Reports
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Articles

A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma

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By Mattie J. Casey, Priya P Chan, QING LI, High-Throughput Genomics
| Cell Reports Verified
Highlights • Zebrafish patched 1 (ptch1) is a conserved tumor-suppressor gene • Somatic and germline mutations in zebrafish ptch1 cause embryonal brain tumors • ptch1-deficient brain tumors model the human SHH medulloblastoma (MB) subgroup • CRISPR screens using zebrafish identify Grk2/3 as a therapeutic target in SHH MB Summary Medulloblastoma (MB) is the most common malignant brain tumor in children and is stratified into three major subgroups.
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