Himani Rana

Short articleOnline nowOpen access Affiliations & Notes 1Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom of Great Britain and Northern Ireland (the) 2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, United States of America 3Department of Cancer and Genomic Sciences, College of Medicine and Health, University of Birmingham,...

My First Medium Post: Here Goes Nothing! So… this is my first post on Medium. Honestly, I have no idea what I’m doing here, but hey, why not give it a shot? What’s the worst that could happen, right? 😅 This moment feels oddly significant—like a mini milestone. I’m trying something entirely out of my comfort zone (well, besides crafting my dating profile sometime back—TMI, I know). Definitely not the usual me. Is it just me, or has working from home completely wrecked everyone’s productivity?

Abstract The succinate dehydrogenase (SDH) is a four-subunit enzyme complex (SDH-a, SDH-b, SDH-c, and SDH-d) central to cell carbon metabolism. The SDH bridges the tricarboxylic acid cycle to the electron transport chain. A pathological loss of the SDH-b subunit leads to a cell-wide signalling cascade that shifts the cell's metabolism into a pseudo-hypoxic state akin to the so-called Warburg effect (or aerobic glycolysis).