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Holly Barrett

As seen in: Cell Press
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Articles

Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes

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By Elya Shamskhou, Fergal Duffy, Lauren Cross, Courtney R Plumlee, Benjamin H. Gern, Holly Barrett, Alan H Diercks, Sara Cohen, Ramya Sivakumar, John Aitchison, Vitaly V Ganusov, Kevin Urdahl, Michael Gerner
| Cell Press Verified
Keywords Mycobacterium tuberculosis lymph node architecture innate cell responses T cell priming BCG vaccination single-cell RNA sequencing dendritic cells monocyte-derived cells bacterial persistence type I interferon Introduction Tuberculosis (TB) remains a leading cause of global mortality caused by a single pathogen, Mycobacterium tuberculosis (Mtb).1 Although pulmonary infection has dominated research focus, Mtb pathogenesis extends beyond the lung to secondary lymphoid organs and other...
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