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A Thermostable mRNA Vaccine against COVID-19

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By Na-Na Zhang, Xiao-Feng Li, Yong-Qiang Deng, Hui Zhao, Yi-Jiao Huang, Peng Gao, Chao Zhou, Yan Guo, Shi-Hui Sun, Hang Fan, Qi Chen, Qi He, Xing-Yao Huang, Wei-Jin Huang, Rong-Rong Zhang, Shu-Long Zu, Tian-Shu Cao, Hong-Ying Qiu, Jian-Hui Nie
| ScienceDirect Verified
Highlights • Development of LNP-encapsulated mRNA vaccine (ARCoV) targeting the RBD of SARS-CoV-2 • ARCoV induces neutralizing antibodies and T cell immunity in mice and NHPs • ARCoV vaccination confers full protection against SARS-CoV-2 challenge in mice • ARCoV is a thermostable vaccine candidate for phase I studies Summary There is an urgent need for vaccines against coronavirus disease 2019 (COVID-19) because of the ongoing SARS-CoV-2 pandemic.
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