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HONGYAN WANG

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Articles

Targeting PID1 generates oxysterols to switch macrophage cell fates for improved antitumor immunity

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By Yuxiao Zheng, Qi Wang, Chen Dong, Qiong Wang, Mingshun Han, Haiqing Zhao, Shuang Wang, Longlong Chen, Xiaoli Zhang, Dan Yang, Jun Xiao, Zhihuan Chew, Zhenfei Xie, Xin Zheng, Weiyun Li, Lijian Hui, Xiaowu Huang, Jinsong Li, Huiru Tang, Bin Wei, HONGYAN WANG, Jinyong Fan, Dezhen Tu, Lingming Zheng
| Nature Verified
Abstract Disordered cholesterol–oxysterol profiles are observed in the tumor microenvironment, yet their roles in tumor-associated macrophages (TAMs) remain underexplored. This study reveals that TAMs across human pan-cancers exhibit elevated phosphotyrosine interaction domain-containing protein 1 (PID1) expression and prominent immunosuppressive gene signatures.
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Nutrition signals the brain to reactivate quiescent neural stem cells

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By HONGYAN WANG
| Nature Verified
Adult neurogenesis is the process by which neural stem cells (NSCs) generate new neurons in the adult mammalian brain, which contributes to learning and memory and supports cognitive resilience during ageing. Deficits in adult neurogenesis have been associated with various neurodevelopmental and neuropsychiatric disorders, as well as neurodegenerative diseases.
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Search Results

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By HONGYAN WANG, Xin Wang, Xiaoqi Sun
| Microbiology Research
Introduction. Biofilm formation and hemolysis are closely related to the pathogenicity of Staphylococcus aureus . Hypothesis/Gap Statement. Strategies that reduce the mortality of S. aureus infections may involve novel antimicrobials and/or drugs that decrease S. aureus virulence, such as biofilm formation. The antiviral drug efavirenz is a non-nucleoside reverse transcriptase inhibitor, which also has shown antibacterial effect on Bacillus subtilis and Escherichia coli .
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