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Full article: Controlling FDR in selecting group-level simultaneous signals from multiple data sources with application to the National COVID Collaborative Cohort data
?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. Abstract One challenge in exploratory association studies using observational data is that the associations between the predictors and the outcome are potentially weak and rare, and the candidate predictors have complex correlation structures.
Bias reduction methods in the hierarchical likelihood approach for shared frailty model of clustered failure time data
Shared frailty models are widely used for the analyses of multivariate survival data. A hierarchical likelihood (h-likelihood) approach has been developed for estimating the regression parameters and frailty variates, in which the latent frailties are treated as ‘parameters’ and estimated jointly with other parameters of interest. The h-likelihood estimators generally perform well in various frailty models. However, they are known to be biased for non-normal random effects.
Changes in quality of life and mental health outcomes related to vaping cessation among US adults
Objectives Vaping cessation has important public health implications. This study seeks to assess longitudinal changes in quality of life and mental health associated with vaping cessation. Methods Data were drawn from the longitudinal wave 5 (December 2018–November 2019) and wave 6 (March 2021–November 2021) of the Population Assessment of Tobacco and Health study, a nationally representative sample of US adults aged 18 and older.
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