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Hongying You

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Poor prognosis of newly diagnosed multiple myeloma patients with 1p32.3 deletion in single monoallelic deletion and/or in main clone

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By Lingzhi Yan, Yingying Zhai, Hongying You, Weiqin Yao
| Wiley Online Library Verified
BACKGROUND Multiple myeloma (MM) is an incurable haematological malignancy characterized by abnormal monoclonal plasma cell proliferation,1 predominantly affecting the elderly, with an incidence of approximately 1.03 per 100 000 annually in China.2 Chromosomal abnormalities, notably chromosome 14 translocations involving the immunoglobulin heavy chain (IgH) gene, hyperdiploidy and other copy number alterations,3, 4 significantly contribute to patient heterogeneity and disease progression.
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