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Hormos S. Dafsari on Muck Rack

Hormos S. Dafsari

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Articles

Vitamin B 12 alleviates spliceosomopathy via phospholipid remodeling

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By Emily Baum, Ivan Dikic, Wenming Huang, Adam Antebi, Jonathan Kölschbach, Hormos S. Dafsari, Anna Löhrke, Chun Kew
| Nature Verified
Abstract mRNA splicing represents a fundamental level of gene regulation that alters proteomic diversity and cellular state. Its dysfunction can profoundly rewire metabolism, yet underlying mechanisms remain elusive. Here, we investigate Verheij syndrome, caused by mutations in core splicing factor PUF60, using a Caenorhabditis elegans model, human cell lines, and patient-derived samples.
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