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Housaiyin Li on Muck Rack

Housaiyin Li

As seen in: The BMJ, Science Magazine, Cell Press
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Articles

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species

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By Shanshan Lian, Anastasia A Minervina, Alexander J. Wesolowski, Ardon M. Pillay, Panagiota Vardaka, Housaiyin Li, Andrew James, Christopher Ward, Teresa von Linde, Alberto Conti, Sheue-Fen Tzeng, Layla Dahmani, Alexander Evans, Sarah Whiteside, Yumi Yamashita-Kanemaru, Charlotte J. Imianowski, Jie Yang, Ignacio González, Jack Chapman, Aws Al-deka, Rabab Nasrallah, Randy Greaves, Iliana Loffreda, Chelsea Jenkin, Alica Nübling
| Science Magazine Verified
Editor’s summary Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Editor’s summary Reactive oxygen species (ROS) have a paradoxical role in cancer. Low to moderate ROS levels can stimulate tumor growth, whereas excessive ROS accumulation triggers oxidative stress and DNA damage.
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Distinct CD8+ T cell dynamics associate with response to neoadjuvant cancer immunotherapies

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By Housaiyin Li, Dan P. Zandberg, Aditi Kulkarni, Simion I. Chiosea, Patricia Santos, Brian R. Isett, Marion Joy, Gabriel Sica, Kevin J. Contrera, Curtis Tatsuoka, Matthias Brand, Umamaheswar Duvvuri, Seungwon Kim, Mark W. Kubik, Shaum Sridharan, Jie Chen, Tullia C. Bruno, Dario A.A. Vignali, Anthony R. Cillo, Riyue Bao, Jing Wang, Lazar Vujanovic, Robert Ferris Verified
| Cell Press Verified
Keywords Head and neck cancer tumor immunology clinical trial single-cell genomics T cell dynamics multispectral imaging combination immunotherapy PD-1 LAG-3 CTLA-4 Introduction While monoclonal antibodies (mAb) targeting the PD-1/PD-L1 pathway have transformed cancer treatment, durable responses are observed only in a minority of cancer patients.1,2,3,4 The limited clinical efficacy of cancer immunotherapy highlights the need to identify reliable markers that can predict responses to immune...
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Differential impact of TIM-3 ligands on NK cell function

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By Juncheng Wang, Aditi Kulkarni, Jennifer Anderson, Housaiyin Li
| The BMJ Verified
Methods K562 cell line was obtained from American Type Culture Collection (Manassas, Virginia, USA).
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