Hreinn Stefánsson on Muck Rack

Hreinn Stefánsson

As seen in: Nature, Biological Psychiatry
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Articles

Mapping the genetic landscape across 14 psychiatric disorders - Nature

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By Andrew Grotzinger, Oleksandr Frei, Christiaan de Leeuw, Joanna M. Biernacka, Ole A. Andreassen, Anders D. Børglum, Gerome Breen, Ditte Demontis, Howard J. Edenberg, Barbara Franke, Michael J. Gandal, Joel Gelernter, Alexander S. Hatoum, Emma Johnson, Katherine Jonas, Travis T. Mallard, Manuel Mattheisen, Benjamin M. Neale, Roseann E. Peterson, Elise B. Robinson, Susan Santangelo, Hreinn Stefánsson, Murray B. Stein, Nora I. Strom, Elliot M. Tucker-Drob, Irwin D. Waldman, G. Bragi Walters, Naomi R. Wray, Obsessive-Compulsive Disorder, Phil Lee, Kenneth S. Kendler
| Nature Verified
Abstract Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar disorder3, genomic methods have revealed that the majority of genetic signal is shared4.
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Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies | Molecular Psychiatry

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By Elise Koch, Guðmundur Karl Einarsson, Brittany Mitchell, Kristi Krebs, Ying Xiong, Oleksandr Frei, Yi Lu, Sara Hägg, Miguel E. Rentería, Sarah E. Medland, Naomi R. Wray, Nicholas Martin, Gerome Breen, Thorgeir E. Thorgeirsson, Hreinn Stefánsson, Kari Stefansson, Lili Milani, Ole A. Andreassen
| Nature Verified
Abstract Antidepressants exhibit a considerable variation in efficacy, and increasing evidence suggests that individual genetics contribute to antidepressant treatment response.
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Sequence diversity lost in early pregnancy - Nature

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By Gudny A. Arnadottir, Hakon Jonsson, Jennifer R. Gruhn, Peter Loof Møller, David Westergaard, Louise le Roux, Valgerdur Steinthorsdottir, Hannes P. Eggertsson, G. Bragi Walters, Hreinn Stefánsson, Agnar Helgason, Palle Duun Rohde, Bjarni V Halldorsson, Sofie Bliddal, Mette Nyegaard, Eva Hoffmann, Henriette Svarre Nielsen
| Nature Verified
Abstract Every generation, the human genome is shuffled during meiosis and a single fertilized egg gives rise to all of the cells of the body1. Meiotic errors leading to chromosomal abnormalities are known causes of pregnancy loss2,3, but genetic aetiologies of euploid pregnancy loss remain largely unexplained4.
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