Hristo Georgiev

Preprint Case Report Version 1 This version is not peer-reviewed Version 1 : Received: 28 October 2024 / Approved: 30 October 2024 / Online: 31 October 2024 (02:49:30 CET) Marinov, K.; Mondeshki, T.; Georgiev, H.; Dimitrova, V.; Mitev, V. Effects of Long-Term Prophylaxis with Bromhexine Hydrochloride and Treatment with High Colchicine Doses of COVID-19. Preprints 2024, 2024102410. https://doi.org/10.20944/preprints202410.2410.v1 Marinov, K.; Mondeshki, T.; Georgiev, H.; Dimitrova, V.; Mitev, V.

Abstract Invariant natural killer T (NKT) cell subsets are defined based on their cytokine-production profiles and transcription factors. Their distribution is different in C57BL/6 (B6) and BALB/c mice, with a bias for NKT1 and NKT2/NKT17 subsets, respectively. Here, we show that the non-classical class I-like major histocompatibility complex CD1 molecules CD1d2, expressed in BALB/c and not in B6 mice, could not account for this difference.

Abstract Conventional T cells are selected by peptide-MHC expressed by cortical epithelial cells in the thymus, and not by cortical thymocytes themselves that do not express MHC I or MHC II. Instead, cortical thymocytes express non-peptide presenting MHC molecules like CD1d and MR1, and promote the selection of PLZF+ iNKT and MAIT cells, respectively. Here, we report an inducible class-I transactivator mouse that enables the expression of peptide presenting MHC I molecules in different cell types.