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Articles

Sensitivity to BUB1B Inhibition Defines an Alternative Classification of Glioblastoma

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By Eunjee Lee, Multiscale Biology, Margaret Pain, Huaien Wang
| cancerres.aacrjournals.org
AbstractGlioblastoma multiforme (GBM) remains a mainly incurable disease in desperate need of more effective treatments. In this study, we develop evidence that the mitotic spindle checkpoint molecule BUB1B may offer a predictive marker for aggressiveness and effective drug response. A subset of GBM tumor isolates requires BUB1B to suppress lethal kinetochore–microtubule attachment defects.
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