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Huangfan Xie

As seen in: Nature, Stem Cell Reports
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Articles

OTX2 inhibits human pluripotent stem cell reprogramming toward 8-cell-like and morula-like states - Nature Communications

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By Shigang Yin, Jianhua Peng, Yong Jiang, Huangfan Xie
| Nature Verified
Abstract In human embryos, major zygotic genome activation (ZGA) initiates at the 8-cell (8C) blastomere stage, marking the start of the ontogenesis program. Recent advancements have shown that primed human pluripotent stem cells (hPSCs) can be reprogrammed to 8C-like cells (8CLCs) with totipotent characteristics in vitro. However, the key regulators driving this transition remain largely unexplored.
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Human pluripotent stem cell-derived eosinophils reveal potent cytotoxicity against solid tumors

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By Biomimetic Drugs, Yuting Liu, Weifeng Lai, Huangfan Xie
| Stem Cell Reports Verified
Highlights • A chemically defined approach generates functional human eosinophils from hPSCs • hPSC-derived eosinophils exhibit competent antitumor ability in vitro and in vivo • Potential synergy of action when both eosinophils and CAR-T cells are used together Summary Eosinophils are attractive innate immune cells to use to potentiate T cell antitumor efficacy because they are capable of infiltrating tumors at early stages and modulating the tumor microenvironment.
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