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Shigang Yin on Muck Rack

Shigang Yin

As seen in: Nature, Wiley Online Library, Cell Metabolism
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Articles

Targeting the FOXP3–T-bet interaction to restore Treg stability in IFN-γ–driven autoimmunity

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By Weiqi Zhang, Xinnan Liu, Zhiyong Gu, Jiahang Xu, Zheng Bao, Rui Liang, Zhenran Xu, Dan Teng, Guojun Qu, Qianru Huang, Yi Lei, Feng Xie, Na Tian, Yichao Han, Siyuan Qiang, Hecheng Li, Guohua Li, Dan Li, Sulin Zhang, Song Zheng, Zhi Liu, Shigang Yin, Mingyue Zheng, Feihong LUO, Xueyu Dai
| Nature Verified
Abstract Regulatory T-cell (Treg) stability is maintained by dynamic remodeling of the FOXP3 transcriptional complex, and disruption of this complex leads to Treg dysfunction and immune dysregulation. However, how specific FOXP3 mutations alter the dynamic remodeling of the FOXP3 complex and thereby contribute to pathogenic Treg reprogramming in IPEX syndrome remains unclear.
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OTX2 inhibits human pluripotent stem cell reprogramming toward 8-cell-like and morula-like states - Nature Communications

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By Shigang Yin, Jianhua Peng, Yong Jiang, Huangfan Xie
| Nature Verified
Abstract In human embryos, major zygotic genome activation (ZGA) initiates at the 8-cell (8C) blastomere stage, marking the start of the ontogenesis program. Recent advancements have shown that primed human pluripotent stem cells (hPSCs) can be reprogrammed to 8C-like cells (8CLCs) with totipotent characteristics in vitro. However, the key regulators driving this transition remain largely unexplored.
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