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Huangqing Zhu

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Articles

Progressive Left Ventricular Pressure Overload Reprograms Neonatal Left Ventricular Development via Sustained Proliferation, Metabolic Arrest, and Compensatory Angiogenesis

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By Sijuan Sun, Zheng Wang, Huangqing Zhu
| Preprints.org
Posted: 02 September 2026 You are already at the latest version Left ventricular pressure overload (LVPO) is a common hemodynamic stressor in pediatric cardiovascular diseases, yet how progressive—rather than fixed—overload reshapes the neonatal left ventricular (LV) developmental program remains largely unexplored. In this study, we established a neonatal rat model of progressive LVPO via abdominal aortic banding surgery (ABS) on postnatal day 1(P1), achieving 100% survival.
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