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Huiying Chu on Muck Rack

Huiying Chu

As seen in: Nature, ACS Publications, Science Magazine, Royal Society of Chemistry, Cell Press
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Articles

An alternative EGFR activation by patient-derived R252C mutation promotes cancer progression - Nature Communications

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By Yajuan Zhang, Dong Gao, Yun Zhao, Guohui Li, Huiying Chu, Wenfeng Li
| Nature Verified
Abstract Mutations in the extracellular or intracellular domains of epidermal growth factor receptor (EGFR) are implicated in the development of various cancers. While the intracellular mutations of EGFR have been extensively studied, the function of extracellular mutations remains poorly understood. In this study, we identify an EGFR mutant (EGFR R252C) in a patient with multifocal lung cancer and glioma, in which arginine (R) 252 is mutated to cysteine (C) in the EGFR extracellular domain.
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Exploring the Mutarotation Mechanism of Glucose in Solution Using Deep Learning Potential

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By Hongqiang Cui, Da Zheng, Huiying Chu, Guohui Li
| dx.doi.org
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UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance

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By Hua Yu, Tiezhu Shi, Huiying Chu, Dongwei Xu, Xiaoyong Gong, Lingyun Xiao, Ye Liu, Qiang Xia, Qi Zhou, Yufeng Ding, Guohui Li, Xiongjun Wang
| Cell Press Verified
Keywords metabolite PKR UGDH TOP2A LLPS liver cancer Get full text access Log in, subscribe or purchase for full access. References 1. Siegel, R.L. ∙ Miller, K.D. ∙ Fuchs, H.E. ... Cancer statistics, 2022 CA Cancer J. Clin. 2022; 72:7-33 2. Chandra, R.A. ∙ Keane, F.K. ∙ Voncken, F.E.M. ... Contemporary radiotherapy: present and future Lancet. 2021; 398:171-184 3. Sgouros, G. ∙ Bodei, L. ∙ McDevitt, M.R. ... Radiopharmaceutical therapy in cancer: clinical advances and challenges Nat. Rev. Drug Discov.
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