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Hundeep Kaur

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Articles

The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase

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By Hundeep Kaur, Roman P. Jakob, Jan K. Marzinek, Robert Green
| Nature Verified
Abstract Antibiotics that target Gram-negative bacteria in new ways are needed to resolve the antimicrobial resistance crisis1,2,3. Gram-negative bacteria are protected by an additional outer membrane, rendering proteins on the cell surface attractive drug targets4,5. The natural compound darobactin targets the bacterial insertase BamA6—the central unit of the essential BAM complex, which facilitates the folding and insertion of outer membrane proteins7,8,9,10,11,12,13.
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By Cláudio Soares, Thomas F. Prisner, Clemens Glaubitz, Hundeep Kaur, Bárbara Abreu, Dmitry Akhmetzyanov, Andrea Lakatos-Karoly
| American Chemical Society
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