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Survivin in breast cancer-derived exosomes activates fibroblasts by up-regulating SOD1, whose feedback promotes cancer proliferation and metastasis
Kangdi Li, Ting Liu, Jie Chen, Huying Ni and Wenhua Li* Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China ↵*For correspondence: Wenhua Li, whli{at}whu.edu.cn. Edited by Eric R. Fearon Abstract Cancer-associated fibroblasts (CAFs) play a critical role in the coevolution of breast tumor cells and their microenvironment by modifying cellular compartments and regulating cancer cell functions via stromal-epithelial dialogue.
Survivin in breast cancer-derived exosomes activates fibroblasts by upregulating SOD1, whose feedback promotes cancer proliferation and metastasis
Abstract Cancer-associated fibroblasts (CAFs) play a critical role in the coevolution of breast tumor cells and their microenvironment by modifying cellular compartments and regulating cancer cell functions via stromal-epithelial dialogue. However, the relationship and interaction between stromal and epithelial cells are still poorly understood.
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