Hwee Ying Lim

Abstract Lymphoedema is a chronic debilitating disease caused by impaired lymphatic drainage and is characterized by tissue swelling, fat expansion, inflammation and fibrosis1,2. However, the exact mechanisms that drive lymphoedema are poorly understood.

Editor’s summary In addition to their role in host defense, macrophages contribute to the development and remodeling of tissues. Yu et al. characterized macrophages found in the adipose tissue of mice on the basis of their gene expression, localization within the tissue, and developmental origin. A subset of macrophages localized in the same tissue microenvironment as adipocyte stem cells and promoted their differentiation into white adipocytes.

Abstract A functional lymphatic vasculature is essential for tissue fluid homeostasis, immunity, and lipid clearance. Although atherosclerosis has been linked to adventitial lymphangiogenesis, the functionality of aortic lymphatic vessels draining the diseased aorta has never been assessed and the role of lymphatic drainage in atherogenesis is not well understood.