Hye-Jung E. Chun on Muck Rack

Hye-Jung E. Chun

As seen in: Cell Press
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Articles

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

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By BC Cancer, Pascal D. Johann, Hye-Jung E. Chun, Katy Milne
| Cell Press
Highlights • MYC subgroup of cranial RTs (ATRT-MYC) is molecularly similar to extra-cranial RTs • Five DNA methylation subgroups are identified in RTs across multiple organ sites • Groups 1, 3, and 4 exhibit cytotoxic T cell infiltration and PD1 and PD-L1 expression Summary Extra-cranial malignant rhabdoid tumors (MRTs) and cranial atypical teratoid RTs (ATRTs) are heterogeneous pediatric cancers driven primarily by SMARCB1 loss.
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