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Hyeon Gu Kang

As seen in: Nature, BioRxiv
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Articles

Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer - Nature Aging

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By Siddhartha Sharma, Neerja Katiyar, Hyeon Gu Kang, Giray N. Eryilmaz, Mark A LaBarge, Jeffrey H. Chuang, Duygu Ucar
| Nature Verified
Abstract Aging is the greatest risk factor for breast cancer; however, how age-related cellular and molecular events impact cancer initiation is unknown. In this study, we investigated how aging rewires transcriptomic and epigenomic programs of mouse mammary glands at single-cell resolution, yielding a comprehensive resource for aging and cancer biology. Aged epithelial cells exhibit epigenetic and transcriptional changes in metabolic, pro-inflammatory and cancer-associated genes.
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Comprehensive single cell aging atlas of mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer

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By Siddhartha Sharma, Hyeon Gu Kang, Brittany L Angarola, Neerja Katiyar
| BioRxiv
Abstract Aging is the greatest risk factor for breast cancer; however, how age-related cellular and molecular events impact cancer initiation is unknown. We investigate how aging rewires transcriptomic and epigenomic programs of mouse mammary glands at single cell resolution, yielding a comprehensive resource for aging and cancer biology. Aged epithelial cells exhibit epigenetic and transcriptional changes in metabolic, pro-inflammatory, or cancer-associated genes.
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Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic Response

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By Byoung-Gie Kim, Hyeon Gu Kang, Haeun Hwangbo
| cancerres.aacrjournals.org
Translational Science Hyeon Gu Kang, Haeun Hwangbo, Myung Ji Kim, Sinae Kim, Eun Ji Lee, Min Ji Park, Jae-Weon Kim, Byoung-Gie Kim, Eun-Hae Cho, Suhwan Chang, Jung-Yun Lee and Jung Kyoon Choi DOI: 10.1158/0008-5472.CAN-21-2023 Published January 2022 Abstract BRCA1/2 mutations account for only a small fraction of homologous recombination (HR) deficiency (HRD) cases.
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