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Articles by Hyewon Chung
Bst2-targeted senotherapy restores visual function by eliminating senescent retinal cells
Abstract Senescent cells contribute to degenerative processes in multiple tissues, including the retina. In the retinal pigment epithelium (RPE), their accumulation is closely associated with retinal aging and disease progression. Eliminating senescent RPE cells has shown therapeutic potential, but conventional senolytics often lack the specificity required to spare non-senescent cells, raising safety concerns.
In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration - Scientific Reports
Abstract Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age‑related macular degeneration (AMD), lead to progressive vision loss through photoreceptor degeneration; RP begins with the gradual loss of peripheral rods, whereas AMD causes central‑vision loss mainly because macular cones and parafoveal rods degenerate. The neural retina leucine zipper (NRL) directs rod photoreceptor differentiation, and its disruption has been linked to upregulated cone-specific markers in rods.
Diagnosis of Pain Deception Using Minnesota Multiphasic Personality Inventory-2 Based on XGBoost Machine Learning Algorithm: A Single-Blinded Randomized Controlled Trial
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Comparison of Long-Term Outcomes in Early-Stage Endometrial Cancer: Robotic Single-Site vs. Multiport Laparoscopic Surgery
1. Introduction Endometrial cancer is the sixth most common cancer among women, with 41,700 newly diagnosed cases worldwide in 2020 [1]. Its estimated age-standardized incidence rate is 8.3 per 100,000 women. In endometrial cancer, surgery is the first diagnostic step, as the biopsy result defines the final diagnostic stage. Surgical staging of endometrial cancer includes total hysterectomy and bilateral salpingo-oophorectomy with lymph-node assessment [2].
Effects of Simvastatin on Pharmacokinetics and Anticoagulant Effects of Dabigatran in Healthy Subjects
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The Role of Metallodrugs in Cellular Senescence
Graphical Abstract Senescence is a double-edged sword that needs to be tackled thoroughly in the field of cancer and aging diseases. This perspective highlights the great possibilities of using senotherapy as a new approach for dealing with cancer and underlines the little research on metal-based drugs in cellular senescence. The scarce examples found reflect the infancy stage of this research. Abstract Delivering alternative strategies to deal with cancer is a huge milestone in research.
Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages
Highlights • The tumor microenvironment increases the activity of PKA-C in macrophages • PKA-Cβ specifies pro-tumoral phenotype of macrophages • Macrophages produce pro-tumoral VEGFA, IL-10, and ARG1 via PKA activity • Therapeutic targeting of PKA-C confers anti-tumor T cell responses Summary As current therapies benefit only a minority of cancer patients, additional therapeutic targets are needed.
A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study
The aim of this study was to explore the pharmacokinetic-pharmacodynamic (PK-PD) relationship of metformin on glucose levels after the administration of 250 mg and 1000 mg of metformin in healthy volunteers. A total of 20 healthy male volunteers were randomized to receive two doses of either a low dose (375 mg followed by 250 mg) or a high dose (1000 mg followed by 1000 mg) of metformin at 12-h intervals.
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