Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Abstract Kaposi’s sarcoma (KS), induced by Kaposi’s sarcoma-associated herpesvirus (KSHV), is a multicentric tumor of lymphatic endothelial origin. However, the fundamental molecular mechanisms underlying the KS progression remain poorly understood.
Abstract The P53-destabilizing TBC1D15-NOTCH protein interaction promotes self-renewal of tumor-initiating stem-like cells (TICs); however, the mechanisms governing the regulation of this pathway have not been fully elucidated. Here, we show that TBC1D15 stabilizes NOTCH and c-JUN through blockade of E3 ligase and CDK8 recruitment to phosphodegron sequences.
Dr. Robert Koch, a German physician scientist, discovered Mycobacterium tuberculosis bacilli as a causative agent of TB over 130 years ago. Dr. Koch’s discovery of M. tuberculosis inspired scientists to initiate the antibiotic era to stop the spread of TB. Dr. Schatz and Dr. Waksman discovered an antibiotic called streptomycin in 1944 which showed impressive results when its anti-TB effect using animal models were examined.
Penn et al. used an affinity tag purification mass spectrometry approach to generate an Mtb-human protein-protein interaction map, uncovering a connection between LpqN, a virulence factor in Mtb, and CBL, a host ubiquitin ligase. CBL suppresses lpqN attenuation and acts as a switch for host antibacterial and antiviral responses.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
