Hyunyun Kim on Muck Rack

Hyunyun Kim

As seen in: The Journal of Clinical Investigation
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Articles

Endothelial extracellular vesicle miR-423-5p regulates microvascular homeostasis and renal function after ischemia-reperfusion injury

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By JCI Insight, Francis Migneault, Alice Doreille, Hyunyun Kim
| The Journal of Clinical Investigation
Abstract Microvascular rarefaction substantially contributes to renal dysfunction following ischemia-reperfusion injury (IRI). We characterized the microRNA signature of extracellular vesicles (EVs) released during endothelial apoptosis to identify biomarkers and regulators of microvascular rarefaction and renal dysfunction. Using in vitro models and RNA-Seq, we found miR-423-5p, let-7b-5p, and let-7c-5p enriched in small EVs from apoptotic endothelial cells.
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