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Ian R Humphreys on Muck Rack

Ian R Humphreys

As seen in: Color Research & Application, Nature, Wiley, Science Magazine, Irish Examiner, BioRxiv, Cell Press, Belfast Telegraph, Belfast News Letter, Finance Digest and
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Articles

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications

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By Chloe Moscrop, Iain A. Perry, Matthew D Hitchings, Simon Eastham, James Cronin, Douglas J. Veale, David Finlay Verified, Linda Sinclair, Benjamin Cravatt, Andrew Hogan, James A. Nathan, Ian R Humphreys, Johan Vande Voorde, Jeffrey McDonald, Gareth Jones, James Pearson Verified, Emma Vincent
| Nature Verified
Abstract α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase that maintains the catalytic function of α-ketoglutarate dehydrogenase (α-KGDH), and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis (RA). However, the importance of ABHD11 in regulating T-cell metabolism and function is yet to be explored. Here, we show that pharmacological inhibition of ABHD11 dampens cytokine production by human and mouse T-cells.
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Computing the Human Interactome

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By Ian R Humphreys, Jimin Pei, Jinuk Kim
| BioRxiv
Abstract Protein-protein interactions (PPI) are essential for biological function. Recent advances in coevolutionary analysis and Deep Learning (DL) based protein structure prediction have enabled comprehensive PPI identification in bacterial and yeast proteomes, but these approaches have limited success to date for the more complex human proteome.
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Property development\'s next chapter: Navigating the liquidity crunch

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By Ian R Humphreys
| Financial Reporter Verified
"The slower sales market combined with protracted transaction cycles, as well as higher costs of living, are all restricting borrower liquidity. However, the most significant contributing factor to the cash shortage is higher interest rates." The liquidity crunch is an issue that all property investors have been experiencing over the past few years.
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