Iftikhar Khan

Listen to article • Sherry Rehman says almost half the budget consumed by debt repayment, calls for governance reforms • Senate opposition leader says rich got relief while poor got levies • PTI leader claims debt rose from Rs44tr to Rs97tr in four years ISLAMABAD: Senators from both sides of the aisle on Monday raised alarm over burgeoning debt obligations that have severely constrained the space for development, social protection, and public investment.

ISLAMABAD: Twelve years after Khyber Pakhtunkhwa became Pakistan’s first province to enact a Right to Information (RTI) law, the Free and Fair Election Network (Fafen) notes the pioneering framework remains “underutilised and vulnerable to disinformation due to weak enforcement and structural gaps”.

Trisubstituted hydroxylamines, or hydroxalogs, display useful properties when employed as bioisosteres of tertiary amines, ethers, and even hydrocarbon moieties as revealed by a matched molecular pair analysis. (1) Such properties include the modulation of logP, logD7.4, solubility, protein plasma binding, membrane permeability, metabolism by liver microsomes and hepatocytes, and reduction in hERG inhibition when compared to isosteric tertiary amines.