Ildem Akerman on Muck Rack

Ildem Akerman

As seen in: Nature, Cell Reports, Inkl
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Articles

A heterozygous CEBPA mutation disrupting the bZIP domain in a RUNX1 and SRSF2 mutational background causes MDS disease progression - Nature Communications

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By Peter Keane, Syed A. Mian, Carl C. Ward, George Murphy, Arwa F. Flemban, Saeed M Kabrah, Eirini P. Papapetrou, Ildem Akerman, Manoj Raghavan, Eva Barragan, Dominique Bonnet, Constanze Bonifer, Khadidja Habel
| Nature
Abstract Myelodysplastic syndrome disease (MDS) is caused by the successive acquisition of mutations and thus displays a variable risk for progression to AML. Mutations in CEBPA are commonly associated with a high risk of disease progression, but whether they are causative for AML development is unclear. To analyse the molecular basis of disease progression we generated MDS patient-derived induced pluripotent stem cells from a low risk male patient harbouring RUNX1/SRSF2 mutations.
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Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

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By Ildem Akerman, Zhidong Tu, Anthony Beucher, Delphine M.Y. Rolando
| hal.science
Article Dans Une Revue Cell Metabolism Année : 2017 Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks Mots clés CRISPR interference PDX1 PLUTO chromatin diabetes lncRNAs long noncoding RNAs pancreatic islets transcriptional networks type 2 diabetes Origine : Publication financée par une institution hal-04406067 , version 1 (19-01-2024) Ildem Akerman, Zhidong Tu, Anthony Beucher, Delphine M.Y. Rolando, Claire Sauty-Colace, et al..
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‘Synthetic’ human embryos created without eggs or sperm

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By Robin Lovell-Badge, Ildem Akerman
| Inkl
The work falls outside current UK legislation and raises ethical and legal issues. Prof Magdalena Zernicka-Goetz, of the University of Cambridge and the California Institute of Technology, described the work on Wednesday at the International Society for Stem Cell Research’s annual meeting in Boston, the Guardian reported. “We can create human embryo-like models by the reprogramming of (embryonic stem) cells,” she told the meeting.
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