Imène Gasmi on Muck Rack

Imène Gasmi

As seen in: MDPI, Cell Press
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Articles

Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity

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By Marieme Ndjim, Imène Gasmi, Fabien Herbert, Charlene Josephine, Julie Bas, Ali Lamrani, Nathalie Coutry, Sylvain Henry Verified, Valérie Zimmermann, Valérie Dardalhon, Marta Campillo Poveda, Evgenia Turtoi, Steeve Thirard, Luc Forichon, Alicia Giordano, Zeinab Homayed, Julie Pannequin, Collette Britton, Eileen Devaney, Tom McNeilly, Rick M. Maizels, Philippe Jay, Claire Ciancia, Sylvie Berrard, Andrei Turtoi, François Gerbe
| Cell Press Verified
Keywords tuft cells acetylcholine type 2 immune responses helminth parasites mast cells innate immunity intestinal epithelium mucosal immunity Introduction Tuft cells are a cellular subset mostly found in digestive and respiratory epithelia and play critical roles in mucosal host defense. In the intestinal epithelium, tuft cells are primarily known for their critical sentinel function during parasite infections.
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Tuft cell-derived acetylcholine is an effector of type 2 immunity and directly targets helminth parasites in the gut lumen

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By Fabien Herbert, Imène Gasmi, Marieme Ndjim, Charlene Josephine
| biorxiv.org
Abstract Upon parasitic helminth infection, activated intestinal tuft cells secrete IL-25, which initiates a type 2 immune response during which lamina propria ILC2s produce IL-13. This causes epithelial remodelling, including tuft cell hyperplasia with an unknown function. We describe a novel cholinergic effector function of tuft cells, which we show are the only epithelial cells expressing Choline Acetyltransferase (ChAT).
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Resistance to Gemcitabine in Pancreatic Cancer Is Connected to Methylglyoxal Stress and Heat Shock Response

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By Rebekah Crake, Imène Gasmi, Jordan Dehaye, Fanny Lardinois
| MDPI
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