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Hedgehog Signaling Regulates Epithelial Morphogenesis to Position the Ventral Embryonic Midline
Highlights • Convergence of the coelomic epithelium involves cell flattening and disorganization • Hh signaling regulates coelomic epithelium morphogenesis and N-cadherin distribution • Sec5 and RhoU function downstream of Hh • Hh signaling controls dorsal mesentery midline positioning Summary Despite much progress toward understanding how epithelial morphogenesis is shaped by intra-epithelial processes including contractility, polarity, and adhesion, much less is known regarding how such...
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