Indigo T.C. Chan on Muck Rack

Indigo T.C. Chan

As seen in: Stem Cell Reports
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RBFOX2-dependent alternative splicing of Numb regulates Notch signaling during muscle stem cell activation

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By Kangning Lin, Jing Liu, Erin H.Y. Tse, Yishu Yin, Anqi Dong, Tom H. Cheung, Indigo T.C. Chan, Lok Pui Ngan
| Stem Cell Reports
Keywords muscle stem cells stem cell activation alternative splicing Rbfox2 Notch Numb Introduction The regenerative capacity of skeletal muscle relies on muscle stem cells (MuSCs), also called satellite cells (SCs) (Mauro, 1961; Zammit et al., 2006). In resting muscle, most SCs remain quiescent until receiving a stimulus, such as acute muscle injury, in which SCs activate, proliferate, differentiate, and fuse to form new muscle fibers (Scharner and Zammit, 2011).
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