Yishu Yin

Abstract Human expansion into deep space necessitates sustainable life support. Current prepackaged food systems face nutritional, logistical, and psychological limits on long missions. Cell agriculture, particularly yeast-based biomanufacturing, emerges as a pivotal solution. Yeast’s genetic flexibility, metabolic resilience, and tolerance to extreme conditions make it an ideal chassis for in-situ food and nutrient production.

Keywords muscle stem cells stem cell activation alternative splicing Rbfox2 Notch Numb Introduction The regenerative capacity of skeletal muscle relies on muscle stem cells (MuSCs), also called satellite cells (SCs) (Mauro, 1961; Zammit et al., 2006). In resting muscle, most SCs remain quiescent until receiving a stimulus, such as acute muscle injury, in which SCs activate, proliferate, differentiate, and fuse to form new muscle fibers (Scharner and Zammit, 2011).