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Indira Barbosa on Muck Rack

Indira Barbosa

As seen in: Nature
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Articles

Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis - Nature Genetics

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By Tetsuichi Yoshizato, Christer Nilsson, Axel Winroth, Indira Barbosa, Margs S. Brennan, Amy Hillen, Eva Hellström-Lindberg, Warren W. Kretzschmar, Petter S. Woll, Stefania Mazzi
| Nature Verified
Abstract Dynamic steady-state lineage contribution of human hematopoietic stem cell (HSC) clones needs to be assessed over time. However, clonal contribution of HSCs has only been investigated at single time points and without assessing the critical erythroid and platelet lineages. Here we screened for somatic mutations in healthy aged individuals, identifying expanded HSC clones accessible for lineage tracing of all major blood cell lineages.
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SF3B1-mutant models of RNA mis-splicing uncover UBA1 as a therapeutic target in myelodysplastic neoplasms - Leukemia

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By Jonas Thier, Sophia Hofmann, Katharina Kirchhof, Gabriele Todisco, Teresa Mortera-Blanco, Ingrid Lilienthal, Dimitris C. Kanellis, Ann-Charlotte Björklund, Jiri Bartek, Nikolas Herold, Elli Papaemmanuil, Eirini P. Papapetrou, Eva Hellström-Lindberg, Pedro Moura, Indira Barbosa, André G. Deslauriers
| Nature Verified
Abstract Myelodysplastic syndromes with somatic mutations in the splicing factor SF3B1 gene (MDS-SF3B1) result in RNA mis-splicing, erythroid dysplasia and ultimately refractory anemia. Precision medicine approaches for MDS-SF3B1 remain challenging due to both the complexity of the mis-splicing landscape and its evaluation in disease-accurate models.
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